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Title:
Bioconcentration and elimination of avermectin B1 in sturgeon.
Authors:
Shen J, Zhang Q, Ding S, Zhang S, Coats JR
Drug:
Avermectin B1
Fish species:
Sturgeon
Date:
2005
t1/2-hr:
104
Sample:
muscle
Ave Weight (gm):
36
Ave Water temp (°C):
20
Water:
Freshwater
Dosage:
1 ng/ml 22d
Route:
BATH
Comments:
Residue dose day22= 38.29+/- 0.1.5ng/g. Withdrawall d22= 2.1 +/-0.19 ng/g, d44=ND. The estimated value of bioconcentration factor was 41 L/kg. BCF for both the the high and low concentrations was not significantly different indicating that Avermectin B1 does not strongly bioconcentrate in aquatic organisms and would not be expected to biomagnify in the food chain. Uptake constant=6.5, elim constant 0.16. Average recoveries of fortified water samples were 80.5% +/- 5.1% for 1 ng/mL, 83.7% +/- 3.8% for 4 ng/mL, and 89.1 +/- 4.0% for 7 ng/mL.
Citation:
Environmental Toxicology and Chemistry 24: 396-399
Link:
http://www.ncbi.nlm.nih.gov/pubmed/15720000?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Genus Species:
Acipenser sp
Drug Class:
Antiparasitic-Avermectin
Wt gm-detail:
35.8+/-4.6g
Water temp (°C)-detail:
20+/-1 C
Dosage-detail:
Flow through 0.2 ng/ml for 22 days.
Method:
HPLC
Authors-red:
Shen J, Zhang Q, Ding S, Zhang S, Coats JR
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