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Title:
Tissue disposition and excretion of 14C-labelled aflatoxin B1 after oral administration in channel catfish.
Authors:
Plakas SM, Loveland PM, Bailey GS, Blazer VS, Wilson GL
Drug:
Aflatoxin B1
Fish species:
Catfish, channel
Date:
1991
t1/2-hr:
4
Sample:
blood, plasma
Ave Weight (gm):
400
Ave Water temp (°C):
28
Water:
Freshwater
Dosage:
250 µg/kg sd
Route:
PO
Comments:
Absorption half-life was 1.5 h; at 96 h AFB residues were measurable only in the plasma, excretory kidney and liver *plasma protein binding 94+/-4% at 1 hr to 96+/-2% at 2 hr. (14C) AFB.
Protein binding:
95+/-2%*
Citation:
Food and Chemical Toxicology 29:12:805-808
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1765324&dopt=Abstract
Genus Species:
Ictalurus punctatus
Drug Class:
Organic-Mycotoxin
t1/2-detail:
3.7 h
Wt gm-detail:
0.3-0.5 kg
Water temp (°C)-detail:
28 C
Dosage-detail:
250 µg/kg sd
Method:
HPLC-Rad
Authors-red:
Plakas SM, Loveland PM, Bailey GS, Blazer VS, Wilson GL
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