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Title:
A Physiologically Based Pharmacokinetic Model for Predicting the Withdraw Period of Oxytetracycline in Cultured Chinook Salmon (Oncorhynchus tshawytscha).
Authors:
Law FCP (1999)
Drug:
Oxytetracycline
Fish species:
Salmon, chinook
Date:
1999
t1/2-hr:
168
est:
est
Sample:
kidney
Ave Weight (gm):
0
Ave Water temp (°C):
9
Water:
Saltwater
Dosage:
Not Specified
Route:
Not Specified
Comments:
Authors developed a 9-compartment PK model for predicting of OTC in Chinook Salmon. Authors validated model using data from Namadari et al.(1996). Model predictied withdraw period (WP) of OTC. 60d at 9C and 49d at 15C. T1/2 est from graph of model data.
Citation:
In: D.J. Smith, W.H. Gingerich and M.G. Beconi-Barker (Eds.). Xenobiotics in Fish. Kluwer Academic/Plenum Publishers. pp. 105-121
Link:
none
Genus Species:
Oncorhynchus tshawytscha
Drug Class:
Antibiotic-Tetracycline
t1/2-detail:
168h est from graph of model data
Wt gm-detail:
Not Specified
Water temp (°C)-detail:
9 C
Method:
PK, model
Authors-red:
Law FCP (1999)
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