Uptake, metabolism, and elimination of niclosamide by fish.
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Dawson VK, Schreier TM, Boogaard MA, Gingerich WH
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Niclosamide-(2,5-Dichloro-4-nitrosalicylanilide)
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Trout, rainbow
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1999
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20
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est
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muscle+skin
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300
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0
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Freshwater
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0.02 mg/L niclosamide + 2.0 mg/L TFM sd of 12h duration
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BATH
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Fish exposed to a combination of 0.02mg/L niclosamide and 2mg/L TFM-(3-trifluoromethyl-4-nitrophenol. Unpublished data by Dawson et al. Cage study performed in a stream. Cmax at 12h=0.04mg/kg. Can metabolize niclosamide to glucuronide conjugate and sulfate ester. Metabolites not found in muscle. No residues detected after 2-3d in freshwater.
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In: D.J. Smith, W.H. Gingerich and M.G. Beconi-Barker (Eds.). Xenobiotics in Fish. Kluwer Academic/Plenum Publishers. pp. 167-176.
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none
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Oncorhynchus mykiss
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Antiparasitic-Niclosamide
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20hr
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200-400 g
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Not Specified
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0.02 mg/L niclosamide + 2.0 mg/L TFM sd of 12h duration
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HPLC
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Dawson VK, Schreier TM, Boogaard MA, Gingerich WH
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