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Title:
Evaluation of a method of intracoelomic catheterization in koi.
Authors:
Lewbart G, Butkus D, Papich M, Coleman A, Krum H, Noga E
Drug:
Enrofloxacin
Fish species:
Carp, common (koi)
t1/2-hr:
74
Sample:
blood, plasma
Ave Weight (gm):
613
Ave Water temp (°C):
19
Water:
Freshwater
Dosage:
10 mg/kg sd
Route:
ICoC
Comments:
Cipro metabolite not found. Cmax = 5.76 g/mL (at 4 hours) Concentrations from graph: 2h = 5.2, 4h = 5.7, 8h = 5, 12h = 3.3, 24h = 3, 48h = 2.5, 72h = 2.2. Elimination rate = 0.0094 L/h, Tmax = 4 h, AUC = 404.61 h g/mL, Vd/F reported = 1312.1 mL/kg, Cl reported = 12.36, AUMC = 41,652 h^2g/mL, MRT = 102.9 h. ICoC= Intracoelomic Catheter.
Cl:
0.012
Vd:
1.312
Metabolites:
Ciprofloxacin
Citation:
J American Veterinary Medical Association 226:784-788
Link:
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15776954&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Genus Species:
Cyprinus carpio
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
13.5969 h
Wt gm-detail:
212-1014 g
Water temp (°C)-detail:
18.5-19.5 C
Dosage-detail:
10 mg/kg sd
Method:
HPLC
Authors-red:
Lewbart G, Butkus D, Papich M, Coleman A, Krum H, Noga E
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