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Title:
Kinetic analysis of oxytretracycline residues in Chinese mitten crab, Eriocheir sinensis, muscle following intramuscular administration.
Authors:
Feng Q, Gao T, Ji H, Jiang X, Liang T, Gu W, Wu G, Gao G, Wang W
Drug:
Oxytetracycline
Fish species:
Crab, Chinese mitten-handed
Date:
2010
t1/2-hr:
196
Sample:
muscle
Ave Weight (gm):
104
Ave Water temp (°C):
18
Water:
Freshwater
Dosage:
8 mg/kg sd
Route:
IM
Comments:
Peak OTC concentratration at 0.5 h = 3.66 ug/ml. AUC calculated to be 265.13 ug/mL. MRT=253.39h. Authors estimated withdrawal time estimated to be 48.29 d.
Cl:
0.030 L*kg/h
Vc:
0.860 L/kg
Vd:
8.50 L/kg
Citation:
J. Fish Disease 33:639-647
Link:
http://dx.doi.org/10.1111/j.1365-2761.2010.01168.x
Genus Species:
Eriocheir sinensis
Drug Class:
Antibiotic-Tetracycline
t1/2-detail:
alpha=25.32h, beta=195.27h
Wt gm-detail:
103.7+/- 7.4 g
Water temp (°C)-detail:
18 +/- 1C
Dosage-detail:
8 mg/kg sd
Method:
HPLC
Authors-red:
Feng Q, Gao T, Ji H, Jiang X, Liang T, Gu W, Wu G, Gao G, Wang W
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