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Title:
Pharmacokinetics of emamectin benzoate administered to Atlantic salmon, Salmo salar L., by intra-peritoneal injection
Authors:
Glover KA, Samuelsen OB, Skilbrei OT, Boxaspen K, Lunestad BT
Drug:
Emamectin benzoate
Fish species:
Salmon, Atlantic
Date:
2010
Sample:
skin
Ave Weight (gm):
50
Ave Water temp (°C):
12.7
Water:
Freshwater
Dosage:
0.8 mg/kg SD
Route:
IP
Comments:
pilot study. Mean concentration of emamectin benzoate in muscle 14 days post-injection = 815.6. Individual injection volumes ranged from 0.04-0.18 mL per fish to achieve identical dosages between fish.For all dosages, skin concentration was considerably higher than muscle. Also, a clear relationship between dose and resultant concentrastion was observed.
Citation:
J. of Fish Diseases 33: 183-186
Link:
http://www3.interscience.wiley.com/journal/122581013/abstract
Genus Species:
Salmo salar
Drug Class:
Antiparasitic-Avermectin
Wt gm-detail:
49.7 (SD16.3)
Water temp (°C)-detail:
12.7 (11.2-14.2)
Dosage-detail:
400 ug/mL=800ug/kg
Method:
HPLC/MS
Authors-red:
Glover K, Samuelsen O, Skilbrei O, Boxaspen K, Lunestad B
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