Quick Links: Skip to main page content
Skip to Search
Skip to Topics Menu
Skip to Common Links
U.S. Food & Drug Administration
Follow FDA
En Español
Search FDA
Home
Food
Drugs
Medical Devices
Radiation-Emitting Products
Vaccines, Blood & Biologics
Animal & Veterinary
Cosmetics
Tobacco Products
PhishPharm - Detail
FDA Home
PhishPharm
Detail
-
Please note:
JavaScript must be enabled for this application to work properly.
Check your settings
if you are unsure if your JavaScript is enabled.
Title:
Enrofloxacin pharmacokinetics in the European cuttlefish, Sepia officinalis, after a single i.v. injection and bath administration.
Authors:
Gore SR, Harms CA, Kukanich B, Forsythe J, Lewbart GA, Papich MG
Drug:
Enrofloxacin
Fish species:
Cuttlefish, European common
Date:
2005
t1/2-hr:
2
Sample:
blood, hemolymph
Ave Weight (gm):
115
Ave Water temp (°C):
25
Water:
Saltwater
Dosage:
5 mg/kg sd
Route:
IV
Comments:
Cipro metabolite was not found. Salinity 32% Hemolymph sampling - naïve pooling (all animals sampled before dose, 3 at times 0.5, 2, 6, 24, 72 and 3 at 1, 3, 12, 48, 72 h). AUC 17.69 ug.h/ml, MRT 1.36, t1/2 alpha=0.47, CL=4.71 ml/min/kg
Cl:
0.28 L/kg/h
Vd:
0.385 L/kg
Metabolites:
Ciprofloxacin
Citation:
J. Veterinary Pharmacology and Therapeutics 28:433-439
Link:
http://dx.doi.org/10.1111/j.1365-2885.2005.00684.x
Genus Species:
Sepia officinalis
Drug Class:
Antibiotic-Quinolone
t1/2-detail:
1.81 h
Wt gm-detail:
87.0-138.2 g
Water temp (°C)-detail:
25 C
Dosage-detail:
5 mg/kg sd
Method:
HPLC
Authors-red:
Gore SR, Harms CA, Kukanich B, Forsythe J, Lewbart GA, Papich MG
-
-