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Title:
Pharmacokinetics of oxytetracycline in the American horseshoe crab,Limulus polyphemus
Authors:
Nolan MW, Smith SA, Jones D
Drug:
Oxytetracycline
Fish species:
Crab, Atlantic horseshoe
Date:
2007
t1/2-hr:
210
Sample:
blood, hemolymph
Ave Weight (gm):
1745
Ave Water temp (°C):
21
Water:
Saltwater
Dosage:
25 mg/kg sd
Route:
PO
Comments:
Auc 55861.81 ug.h/ml, MRT 395.89 h, Cmax=7.83 ug/ml, Cave=2.89 ug/ml, F=61.56%, salinity 27-29. Hemolymph levels rose again at 20-30 d ost dose, possible enterohepatic recirculation.
Cl:
0.0043
Vd:
1.688
Citation:
J. Veterinary Pharmacology and Therapeutics 30:451-455
Link:
http://www.ncbi.nlm.nih.gov/pubmed/17803738?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Genus Species:
Limulus polyphemus
Drug Class:
Antibiotic-Tetracycline
t1/2-detail:
210 h
Wt gm-detail:
male 760+/-100 female 2730+/-290g
Water temp (°C)-detail:
19-22 C
Dosage-detail:
25 mg/kg sd
Method:
HPLC
Authors-red:
Nolan MW, Smith SA, Jones D
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