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Title:
In vivo acetylcholinesterase inhibition, metabolism, and toxicokinetics of aldicarb in channel catfish: role of biotransformation in acute toxicity.
Authors:
Perkins EJ Jr, Schlenk D
Drug:
Aldicarb
Fish species:
Catfish, channel
Date:
2000
t1/2-hr:
2
Sample:
blood, plasma
Ave Weight (gm):
750
Ave Water temp (°C):
22
Water:
Freshwater
Dosage:
0.32 mg sd
Route:
IVC
Comments:
(14C)-Aldecarb. Cannulated fish. Conc ng/ml 1h=80, 3h=70, 6h=20, 12h=1. Sulfoxide ng/ml 0.04h=12, 0.06h=30, 0.17=45, 0.5=45, 1h=55, 3h=65, 6h=75, 12h=65, 24h=65, 36h=60, 48h=25 ng/ml. AUC=490.8 Trout metabolize 3X more to the sulfoxide by 3 hrs than do catfish.
Cl:
0.65 L/h
Vd:
1.9 L/kg
Metabolites:
Sulfoxide, Sulfone
Citation:
Toxicological Sciences 53:308-315
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10696779
Genus Species:
Ictalurus punctatus
Drug Class:
Carbamate-Pesticide
t1/2-detail:
1.9 h
Wt gm-detail:
700-800
Water temp (°C)-detail:
18-25 C
Dosage-detail:
0.32 mg sd
Method:
HPLC-Rad
Authors-red:
Perkins EJ Jr, Schlenk D
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