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Title:
Toxicity and pharmacokinetics of the antibiotic fumagillin in yearling rainbow trout (Salmo gairdneri).
Authors:
Lauren DJ, Wishkovskiy A, Groff JM, Hedrick RP, Hinton DE
Drug:
Fumagillin
Fish species:
Trout, rainbow
Date:
1989
t1/2-hr:
177
Sample:
blood, plasma
Ave Weight (gm):
314
Ave Water temp (°C):
15
Water:
Freshwater
Dosage:
3 mg/kg or 6 mg/kg sd
Route:
IVC
Comments:
Ffish were catheterized
Vd:
0.231+/-.064 L/kg
Citation:
Toxicology and Applied Pharmacology 98:444-453
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2718173&dopt=Abstract
Genus Species:
Oncorhynchus mykiss
Drug Class:
Antibiotic-Fumagillin
t1/2-detail:
7734+/-2960 min (5.4 d)
Wt gm-detail:
313.6 +/-19.6
Water temp (°C)-detail:
15 C
Dosage-detail:
3 or 6 mg/kg
Method:
HPLC
Authors-red:
Lauren DJ, Wishkovskiy A, Groff JM, Hedrick RP, Hinton DE
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