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Title:
Bioavailability, disposition and pharmacokinetics of 14C-ormetoprim in rainbow trout (Salmo gairdneri).
Authors:
Droy BF, Goodrich MS, Lech JJ, Kleinow KM
Drug:
Ormetoprim
Fish species:
Trout, rainbow
Date:
1990
t1/2-hr:
18
Sample:
blood, plasma
Ave Weight (gm):
500
Ave Water temp (°C):
14
Water:
Freshwater
Dosage:
8 mg/kg sd
Route:
IVC
Comments:
See protein binding info; 33.3+/-3.8% OMP bound at 1h and 31.3+/-3.3% at 6h after IV. Low (<30%) OMP protein binding, non-specific, non-saturable, Ormetoprim (14C).
Protein binding:
Yes
Citation:
Xenobiotica 20:2:147-157
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2333711&dopt=Abstract
Genus Species:
Oncorhynchus mykiss
Drug Class:
Antibiotic-Sulfa
Wt gm-detail:
382-606g
Water temp (°C)-detail:
14+/-1.0C
Dosage-detail:
8 mg/kg sd
Method:
Rad
Authors-red:
Droy BF, Goodrich MS, Lech JJ, Kleinow KM
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