Quick Links: Skip to main page content
Skip to Search
Skip to Topics Menu
Skip to Common Links
U.S. Food & Drug Administration
Follow FDA
En Español
Search FDA
Home
Food
Drugs
Medical Devices
Radiation-Emitting Products
Vaccines, Blood & Biologics
Animal & Veterinary
Cosmetics
Tobacco Products
PhishPharm - Detail
FDA Home
PhishPharm
Detail
-
Please note:
JavaScript must be enabled for this application to work properly.
Check your settings
if you are unsure if your JavaScript is enabled.
Title:
Fate and distribution of the herbicides 2,4-Dichloro-phenoxyacetic acid (2,4-D) and 2,4,5-Trichlorophenoxy-acetic acid (2,4,5-T) in the dogfish shark.
Authors:
Guarino AM, James MO, Bend JR
Drug:
DCPA-(2,4-Dichlorophenoxyacetic acid)
Fish species:
Shark, picked dogfish
Date:
1977
t1/2-hr:
1
Sample:
blood, plasma
Ave Weight (gm):
5000
Ave Water temp (°C):
0
Water:
Saltwater
Dosage:
1 mg/kg sd
Route:
IV
Comments:
Vd= 17.8 +/- 2.8 % of body weight, 57.7 +/- 1.0% at 7µg/ml, DCPA-(2,4-Dichlorophenoxyacetic acid (14C). Ambient temp seawater Maine.
Protein binding:
0.577
Vd:
17.8 +/- 2.8 % of body weight
Metabolites:
Taurine conjugates
Citation:
Xenobiotica 7:10:623-631
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=910463&dopt=Abstract
Genus Species:
Squalus acanthias
Drug Class:
Organic-Chlorinated-Pesticide
t1/2-detail:
44 min
Wt gm-detail:
3-7 kg
Water temp (°C)-detail:
Not Specified
Dosage-detail:
1 mg/kg sd
Method:
Rad
Authors-red:
Guarino AM, James MO, Bend JR
-
-