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Supra Sulfa<sup>®</sup> III Boluses are indicated for the treatment of the following diseases when caused by one or more of the following pathogenic organisms sensitive to sulfamethazine: Bacterial Pneumonia and Bovine Respiratory Disease Complex (Shipping Fever Complex) (<content styleCode="italics">Pasteurella</content> spp.), Colibacillosis (Bacterial Scours) (<content styleCode="italics">E. Coli</content>), Necrotic pododermatitis (Foot Rot), Calf Diphtheria (<content styleCode="italics">Fusobacterium necrophorum</content>), Acute Metritis (<content styleCode="italics">Streptococcus</content> spp.).</paragraph> </text> <effectiveTime value="20231011"/> </section> </component> <component> <section ID="Lbff485a1-8838-481c-9b49-8804c269f4b1"> <id root="a2484551-97e9-40b5-9228-0a4d60e20d8a"/> <code code="53412-3" codeSystem="2.16.840.1.113883.6.1" displayName="RESIDUE WARNING SECTION"/> <text> <paragraph> <content styleCode="bold">RESIDUE WARNING:</content> Treated animals intended for human consumption should not be slaughtered for food for at least 12 days after the last dose. Exceeding two (2) consecutive doses may cause violative tissue residues to remain beyond the withdrawal time. Do not use in female dairy cattle 20 months of age or older. Use of sulfamethazine in this class of cattle may cause milk residues. Do not use in calves under one (1) month of age or calves being fed an all-milk diet. Use in these classes of calves may cause violative residues to remain beyond the withdrawal time.</paragraph> </text> <effectiveTime value="20231011"/> </section> </component> <component> <section ID="L53f30905-8036-4886-a959-fcc87bf156aa"> <id root="97fe8275-b7a8-408c-bb5b-bc9623ff9bb3"/> <code code="42232-9" codeSystem="2.16.840.1.113883.6.1" displayName="PRECAUTIONS SECTION"/> <text> <paragraph> <content styleCode="bold">CAUTION</content>: This drug, like all sulfonamides, may cause toxic reactions and irreparable injury unless administered with adequate and continuous supervision;<content styleCode="bold"> follow recommended dosages carefully.</content> </paragraph> <paragraph>Fluid intake must be adequate at all times throughout the three-day therapy provided by the sustained release bolus. This product has not been shown to be effective for non-ruminating calves.</paragraph> </text> <effectiveTime value="20231011"/> </section> </component> <component> <section ID="L89c96d12-0003-42b7-9cc3-294f41b1987e"> <id root="88fe8937-0706-4373-bb55-15dc0fed7e00"/> <code code="34068-7" codeSystem="2.16.840.1.113883.6.1" displayName="DOSAGE & ADMINISTRATION SECTION"/> <text> <paragraph> <content styleCode="bold">DOSAGE AND ADMINISTRATION:</content> Supra Sulfa<sup>®</sup> III Boluses (sulfamethazine) are designed to be administered orally to beef cattle and non-lactating dairy cattle <content styleCode="bold">(See RESIDUE WARNING Statement)</content>. Supra Sulfa<sup>®</sup> III Boluses should be given according to the following dosage schedule:</paragraph> <paragraph> <renderMultiMedia referencedObject="L7c0184d7-4545-459b-b16b-989cc43a1ea3"/> </paragraph> <paragraph>This bolus may be divided for better approximation of correct dose; however, care should be taken not to crush the bolus. Care should also be taken to ensure the entire dose has been swallowed by the animal. Observe animals following administration to ensure boluses are not regurgitated. Lubricate bolus before dosing animals.</paragraph> <paragraph>Supra Sulfa<sup>®</sup> III Boluses are designed to provide a therapeutic sulfamethazine level in approximately 6 hours and persist in providing this level for 72 hours (3 days). After 72 hours, all animals should be re-examined for persistence of observable disease signs. If signs are present, consult a veterinarian. 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                     <br/>
                     <content styleCode="bold">SUSTAINED RELEASE BOLUS (72 HOURS)</content>
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                     <content styleCode="bold">NOT FOR HUMAN USE</content>
                     <br/>
                     <content styleCode="bold">KEEP OUT OF REACH OF CHILDREN</content>
                     <br/>Approved by FDA under NADA # 120-615</paragraph>
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                  <paragraph>Supra Sulfa<sup>®</sup> III Boluses (sulfamethazine) are intended for oral administration to beef cattle and non-lactating dairy cattle <content styleCode="bold">(See RESIDUE WARNING Statement)</content>. Supra Sulfa<sup>®</sup> III Boluses are indicated for the treatment of the following diseases when caused by one or more of the following pathogenic organisms sensitive to sulfamethazine: Bacterial Pneumonia and Bovine Respiratory Disease Complex (Shipping Fever Complex) (<content styleCode="italics">Pasteurella</content> spp.), Colibacillosis (Bacterial Scours) (<content styleCode="italics">E. Coli</content>), Necrotic pododermatitis (Foot Rot), Calf Diphtheria (<content styleCode="italics">Fusobacterium necrophorum</content>), Acute Metritis (<content styleCode="italics">Streptococcus</content> spp.).</paragraph>
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                     <content styleCode="bold">DOSAGE AND ADMINISTRATION:</content> Supra Sulfa<sup>®</sup> III Boluses (sulfamethazine) are designed to be administered orally to beef cattle and non-lactating dairy cattle <content styleCode="bold">(See RESIDUE WARNING Statement)</content>. Supra Sulfa<sup>®</sup> III Boluses should be given according to the following dosage schedule:</paragraph>
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                  <paragraph>Supra Sulfa<sup>®</sup> III Boluses are designed to provide a therapeutic sulfamethazine level in approximately 6 hours and persist in providing this level for 72 hours (3 days). After 72 hours, all animals should be re-examined for persistence of observable disease signs. If signs are present, consult a veterinarian. It is strongly recommended that a second dose be given to provide for an additional 72 hours of therapy particularly in those more severe cases. The dosage schedule should be used at each 72 hour interval.</paragraph>
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