Zoetis Inc.

Cestex epsiprantel epsiprantel epsiprantel 219 bi-convex Cestex epsiprantel epsiprantel epsiprantel 220 bi-convex Cestex epsiprantel epsiprantel epsiprantel 221 bi-convex Cestex epsiprantel epsiprantel epsiprantel peach 222 bi-convex

Cestex (epsiprantel) tablets are indicated for the removal of tapeworms in the cat (Dipylidium caninum and Taenia taeniaeformis) and dog (Dipylidium caninum and Taenia pisiformis).

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Cestex tablets are film-coated and contain 12.5 mg, 25 mg, 50 mg or 100 mg of epsiprantel per tablet. Epsiprantel is an anthelmintic that is active as a single dose against the common tapeworms of cats and dogs. Epsiprantel has a molecular weight of 326 and is chemically 2-(cyclohexyl-carbonyl)-4-oxo 1,2,3,4,6,7,8,12b-octahydropyrazino[2,1-a][2]benza-zepine. It is a stable white solid which is sparingly soluble in water. Its chemical structure is presented below. Chemical Structure

Epsiprantel acts directly on the tapeworm. Since it is minimally absorbed following oral administration, epsiprantel remains at the site of action within the gastrointestinal tract. Due to digestive process, tapeworm fragments or proglottids may not be readily visible in the stool.


Cestex tablets are indicated for the removal of the following: Feline cestodes: Dipylidium caninum and Taenia taeniaeformis Canine cestodes: Dipylidium caninum and Taenia pisiformis

There are no known contraindications to the use of this drug.

For use in cats and dogs only. Safety of use in pregnant or breeding animals has not been determined. Keep out of reach of children. Not for use in humans.

Do not use in kittens or puppies less than 7 weeks of age.

Cestex tablets should be administered orally. The recommended dosage of epsiprantel is: cats, 1.25 mg/lb of body weight; dogs, 2.5 mg/lb of body weight. The following table may be used as a guide:

Dosage Schedule

Feline
Body Weight	Dose
Seven weeks old up to 10 lb	12.5 mg
11–20 lb	25.0 mg
Canine
Body Weight	Dose
Seven weeks old up to 5 lb	12.5 mg
6–10 lb	25.0 mg
11–20 lb	50.0 mg
21–40 lb	100.0 mg
41–50 lb	125.0 mg
51–60 lb	150.0 mg
61–80 lb	200.0 mg
81–90 lb	225.0 mg
91–100 lb	250.0 mg
101+ lb	2.5 mg/lb, rounding up to next whole tablet combination

Fasting is not necessary or recommended. Unless exposure to the infected intermediate hosts is controlled, reinfection is likely and retreatment may be required. In the case of D. caninum, an effective flea control program should be instituted.

Epsiprantel has been evaluated in cats at 5 times the recommended dose given once daily for 3 days with no adverse effects noted. In tolerance studies, epsiprantel produced minimal clinical signs in cats given 40 times the recommended dose once daily for 4 days. Epsiprantel has been evaluated in 14-day repeat dose studies in dogs at 500 mg/kg (90 times recommended dosage) with no significant adverse results. No side effects were observed during the clinical field studies. Epsiprantel is not a cholinesterase inhibitor. During the course of clinical field studies, Cestex was administered concurrently with diethylcarbamazine citrate (dogs only), anti-inflammatory agents, insecticides, and nematocides with no drug incompatibilities noted.

Store at controlled room temperature 20°-25°C (68°-77°F) with excursions between 15°-30°C (59°-86°F).

Cestex tablets are film-coated and contain 12.5 mg, 25 mg, 50 mg or 100 mg of epsiprantel per tablet. Cestex is supplied as described below:

	Weight (lbs)		Number
Concentration	Cat	Dog	Tablets/Bottle
12.5 mg	10	5	50, 100
25.0 mg	20	10	50, 100
50.0 mg	– –	20	25, 50
100.0 mg	– –	40	25, 50

Cestex ®
(epsiprantel) Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian. 12.5 mg 50 tablets Approved by FDA under NADA # 140-893 zoetis 12.5 mg bottle label


25 mg bottle label


50 mg bottle label


100 mg bottle label