Olympus reviewed the following literature article: "propensity score matching analysis to evaluate efficacy of polyethylene oxide adhesive on preventing delayed bleeding after gastric endoscopic submucosal dissection" by yang yu, et al. regardless of technical advancements, delayed bleeding is still a common adverse event after gastric endoscopic submucosal dissection (esd), often occurring in the early postoperative phase.This study aimed to evaluate the efficacy of a newly designed polyethylene oxide (peo) adhesive for preventing delayed gastric bleeding.Patients who underwent gastric esd between december 2017 and december 2020 at three chinese institutions were retrospectively reviewed.Patients receiving peo application on gastric post-esd ulcers were included in the peo group, and patients without this procedure were included in the control group.To minimize potential bias, propensity score matching was performed, and sex, age, lesion size, lesion morphology, ulceration, localization, procedure time, frequency of major intraoperative bleeding, resected specimen size, lesion histopathology, submucosal invasion and the taking of antithrombotic drugs were included as matching factors.The incidence of delayed bleeding and time to bleeding were compared between both groups.After propensity score matching, 270 patients (135 per group) were included in the analysis.The delayed bleeding rate in the peo group was significantly lower than that in the control group (1.5%, 2/135 vs.8.9%, 12/135, p= 0.006).The median time (range) to bleeding was 4.5 (4¿5) days in the peo group and 2 (1¿15) days in the control group, with no significant difference (p= 0.198).Peo demonstrated a significant effect in reducing the rate of delayed bleeding.Further study is warranted to confirm the efficacy of peo for bleeding that occurs in the early phase after gastric esd.Adverse events: n = 1 experienced haemorrhagic shock on pod1 with transient tachycardia and hypotension, and he also received a blood transfusion because of a decrease in haemoglobin from 101 to 62 g/l.After endoscopic haemostasis and conventional medical treatment, the patient¿s condition stabilized on the same day, and he was discharged on n = >14 - for patients with delayed bleeding, endoscopic haemostasis was successfully performed primarily with electrocoagulation for all bleeding sites.Metal clips were used as combined therapy for 5 lesions.Immediate haemostasis was achieved in all cases, and no re-bleeding events occurred later.N= 4: major intraoperative bleeding was arteriolar bleeding or diffuse venous bleeding in which haemorrhagic sites could not be located for the first time.The article includes 6 reports: patient identifier (b)(6) kd-650u, patient identifier (b)(6) gif-hq290, patient identifier (b)(6) ucr, patient identifier (b)(6) fd-411ur, patient identifier (b)(6) nm-200l-0423, patient identifier (b)(6) gif-q260j.This report is 3 of 6 for patient identifier (b)(6) ucr.
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