Possible side effects which may occur are listed in respective product ifu: adverse reactions: (bio-oss).Incompatibility reactions with geistlich bio-oss® cannot be excluded.Possible complications which may occur with any surgery include swelling at the surgical site, flap sloughing, bleeding, local inflammation, bone loss, infection or pain.Geistlich® bio-oss is a bovine bone-derived material obtained separating the mineral part of the bone from all organic material.Consequently, it is theoretically free of potential allergens, as expected from the fact that the levels of organic substances in geistlich® bio-oss are under the detection limit of the current methodology.Additional information had been inquired but despite the efforts made additional data requested were not provided in order to perform the evaluation.Based on the information received, it is not clear why in this case the clinical outcome has not been successful as expected.There are no details with respect to the choice of treatment method intra-operative and post-surgical medications which could negatively influence the outcome of the treatment.
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