False positive and/or invalid results may be generated in rare cases where a sample contains examples of molecular events that affect the blood-group antigen expression and phenotypes and the nucleotide changes associated with these events are not explicitly monitored by the assay.Examples include dna-sequence variations including premature stop codon, snp leading to missense change in amino acid, hybrid genes, modifying genes; changes at the rna transcription level including alternative splicing; reduced protein expression, etc.Known phenotypes are knull, jknull (jknull has a prevalence of up to 9% among polynesians), rhnull, rh hybrids, kmod, co(a-,b-), in(lu), lu(a-,b-) and gp hybrids.Presence of a c.179_180del (ser60fs) mutation linked with the fy(b) allele may change the fy(b) antigen expression and lead to a false positive result.In this case the patient was reported to be af asian decent.Blood sample was sent for sequencing on (b)(6) 2014.Awaiting sequencing results.
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