Please note that this date is based off of the date of publication of the article as the event dates were not provided in the published literature.It was not possible to ascertain specific device information from the article or to match the events reported with previously reported events.Correspondence has been sent to the author of the article inquiring about individual patient information and additional information regarding the reported events.Concomitant medical products: product id: 3887, lot# unknown, product type: lead.(b)(4).
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Luyten, l., hendrickx, s., raymaekers, s., gabriels, l., nuttin, b.Electrical stimulation in the bed nucleus of the stria terminalis alleviates severe obsessive-compulsive disorder.Molecular psychiatry.2015.1-9.Doi: 10.1038/mp.2015.124 summary: in 1998, we proposed deep brain stimulation as a last-resort treatment option for patients suffering from severe, treatment-resistant obsessive-compulsive disorder (ocd).Here, 24 ocd patients were included in a long-term follow-up study to evaluate the effects of electrical stimulation in the anterior limbs of the internal capsule (alic) and bed nucleus of the stria terminalis (bst).We find that electrical stimulation in the alic/bst area is safe and significantly decreases obsessions, compulsions, and associated anxiety and depressive symptoms, and improves global functioning in a blinded crossover trial (n = 17), after 4 years (n = 18), and at last followup (up to 171 months, n = 24).Moreover, our data indicate that bst may be a better stimulation target compared with alic to alleviate ocd symptoms.We conclude that electrical stimulation in bst is a promising therapeutic option for otherwise treatment resistant ocd patients.Reported events: patient 13: one (b)(6) male patient with bilateral deep brain stimulation (dbs) targeting the bed nucleus of the stria terminalis (bst) to treat obsessive compulsive disorder (ocd) experienced a tonic-clonic epileptic seizure 32 months after implant.This was considered "probably stimulation induced." in addition, it was noted that the patient displayed no quantifiable neurological or cardiovascular abnormalities, as assessed with interictal electroencephalogram and holter monitoring.The author stated that this patient was one of two patients with tonic-clonic insults; one of these patients had a history of head and spine trauma and was under the influence of alcohol (5 units) and sleep deprivation, the other patient was not sleep-deprived, but known to be a moderate alcohol abuser (2-3 units per day).Due to a lack of information, it is unclear if this patient had pre-existing head/spine trauma.Further information has been requested; a supplemental report will be submitted if additional information is received.
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