The distributor reported that an elderly man was treated via trans arterial chemoembolization (tace) using an intravenous injection of cisplatin followed by embolization with embosphere on (b)(6) 2016.Immediately after the infusion of embosphere, a vascular lake appeared inside the tumor.On (b)(6), 2016 pyrexia did not improve, liver disorder persisted, and dyspnea developed.Septic shock due to infection after tace and dic were suspected.The patient was transferred to another hospital, and the general condition of the patient was managed in the intensive care unit from (b)(6) 2016.Liver abscess drainage and antibiotic therapy were performed.On (b)(6) 2016 pyrexia developed, and increased c-reactive protein levels were noted.A switch to meropenem hydrate at 3 g/day was thus made.On (b)(6) 2016 pneumonia developed.Sputum culture yielded positive results for (b)(6), and administration of vancomycin hydrochloride was thus initiated.On (b)(6) 2016 enlarged liver abscess in segment 8 was noted and a drainage tube was placed.On (b)(6) 2016 increased pleural effusion was noted, and left pleural fluid was drained.On (b)(6) 2016 worsening respiratory status was noted.On (b)(6) 2016 liver abscess in segment 7 was confirmed to have shrunk and the drainage tube was removed.An additional drainage tube was placed for liver abscess in segment 8.On (b)(6) 2016 the patient was hospitalized again.The patient died on an unknown day in (b)(6) 2017.The distributor stated that investigational results revealed that worsening of the primary disease and a persistent tumor-associated infection resulted in the patient's death.
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