Sequencing results interpretation: the molecular presence of both guanine and adenine at the polymorphic site indicative of the jka/b antigen would normally represent a heterozygous jkab individual1, as reported by precisetype hea beadchip heaf0737_a7.However, the individual is also heterozygous for a polymorphism at c.956c>t in exon 10 (p.Thr319met, isbt=jk*01n.04) that silences the expression of the jka antigen.The silencing of jka, as first reported by wester et al.2, would leave no expression of the jka antigen on the surface of the erythrocyte.Jknull is listed as a limitation of the precisetype¿ hea beadchip test as listed in the package insert (part number 190-20210).(b)(4).
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