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J Exp Med 2005 Jul 18;202(2):309-19

CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo.

Cowley SC, Hamilton E, Frelinger JA, Su J, Forman J, Elkins KL

Elkins KL, US FDA, Ctr Biol Evaluat & Res, Lab Mycobacterial Dis & Cellular Immunol, Rockville, MD 20852 USA US FDA, Ctr Biol Evaluat & Res, Lab Mycobacterial Dis & Cellular Immunol, Rockville, MD 20852 USA Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75390 USA


Memory T cells, including the well-known CD4(+) and CD8(+) T cells, are central components of the acquired immune system and are the basis for successful vaccination. After infection, CD4(+) and CD8(+) T cells expand into effector cells, and then differentiate into long-lived memory cells. We show that a rare population of CD4(-)CD8(-)CD3(+)alphabeta(+)gammadelta(-)NK1.1(-) T cells has similar functions. These cells potently and specifically inhibit the growth of the intracellular bacteria Mycobacterium tuberculosis (M. tb.) or Francisella tularensis Live Vaccine Strain (LVS) in macrophages in vitro, promote survival of mice infected with these organisms in vivo, and adoptively transfer immunity to F. tularensis LVS. Furthermore, these cells expand in the spleens of mice infected with M. tb. or F. tularensis LVS, and then acquire a memory cell phenotype. Thus, CD4(-)CD8(-) T cells have a role in the control of intracellular infection and may contribute to successful vaccination.

Category: Journal Article
PubMed ID: #16027239
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2011-10-04 Entry Last Modified: 2012-08-29