Scientific Publications by FDA Staff

Bioorg Med Chem 2010 Mar 15;18(6):2135-40

SAR and molecular mechanism study of novel acylhydrazone compounds targeting HIV-1 CA.

Jin Y, Tan Z, He M, Tian B, Tang S, Hewlett I, Yang M

We synthesized a series of acylhydrazone compounds bearing naturally occurring amino acids' side chains as HIV assembly inhibitors. Biological evaluation indicated that the compounds had anti-SIV and capsid assembly inhibitory activities. The structure-activity relationship (SAR) study showed that compounds bearing proper aromatic side chains had potential antiviral activities. The molecular modeling experiments revealed the molecular mechanism that they could bind to CA in the same manner as CAP-1 and occupy two more grooves.