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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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Clin Lab Med 2010 Jun;30(2):381-9

Setbacks in blood substitutes research and development: a biochemical perspective.

Alayash AI


Recent setbacks in using Hb-based technology to develop oxygen carriers or blood substitutes may spur new and fundamentally different approaches for the development of a new generation of hemoglobin-based oxygen carriers (HBOCs). This article briefly details some underlying mechanisms that may have been responsible for the adverse-event profile associated with HBOCs, with a focus on the contribution of the author's laboratory toward identifying some of these biochemical pathways and some ways and means to control them. It is hoped that this will aid in the development of a safe and effective second generation of HBOCs.

Category: Journal Article
PubMed ID: #20513557
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2011-10-04 Entry Last Modified: 2012-08-29