• Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

  • Print
  • Share
  • E-mail

Search Publications



Starting Date

Ending Date

Order by

Entry Details

J Virol 2011 Jun;85(12):6082-5

Discrimination of mumps virus small hydrophobic gene deletion effects from gene translation effects on virus virulence.

Malik T, Shegogue CW, Werner K, Ngo L, Sauder C, Zhang C, Duprex WP, Rubin S


Deletion of the small hydrophobic (SH) protein of certain paramyxoviruses has been found to result in attenuation, suggesting that the SH protein is a virulence factor. To investigate the role of the mumps virus (MuV) SH protein in virulence, multiple stop codons were introduced into the ORF of a MuV molecular clone, preserving genome structure, but precluding production of the SH protein. No differences in neurovirulence were seen between the wild-type and the SHstop viruses. In contrast, upon deletion of the SH gene significant neuroattenuation was observed. These data indicate that the MuV SH protein is not a neurovirulence factor and highlight the importance of distinguishing gene deletion effects from protein-specific effects.

Category: Journal Article
PubMed ID: #21471236 DOI: 10.1128/JVI.02686-10
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2011-10-03 Entry Last Modified: 2012-08-29