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Virol J 2011 Sep 20;8:443

Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection.

Ravichandran V, Major EO, Ibe C, Monaco MC, Girisetty MK, Hewlett IK


BACKGROUND: Xenotropic Murine Leukemia Virus-related (XMRV) virus is a recently identified mouse gammaretrovirus that has the ability to infect certain human cells. In this study, we investigated the susceptibility of primary neuronal cell types to infection with XMRV. FINDINGS: We observed that the human primary progenitors, progenitor-derived neurons, and progenitor-derived astrocytes supported XMRV multiplication. Interestingly, both progenitors and progenitor-derived neurons were more susceptible compared with progenitor-derived astrocytes. In addition, XMRV-infected Jurkat cells were able to transmit infection to neuronal cells. CONCLUSIONS: These data suggest that neuronal cells are susceptible for XMRV infection.

Category: Journal Article
PubMed ID: #21933387 DOI: 10.1186/1743-422X-8-443
PubMed Central ID: #PMC3192781
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2011-10-04 Entry Last Modified: 2012-08-29