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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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Photochem Photobiol 1981 Jan;33(1):123-5

UV-enhanced reactivation in mammalian cells: increase by caffeine.

Lytle CD, Iacangelo AL, Lin CH, Goddard JG


It has been reported that caffeine decreases UV-enhanced reactivation of UV-irradiated Herpes simplex virus in CV-1 monkey kidney cells. That occurred when there was no delay between cell irradiation and virus infection. In the present study, virus infection was delayed following cell irradiation to allow an `induction¿period separate from the `expression¿period which occurs during the virus infection. Thus, the effects of caffeine on `induction¿and `expression¿could be determined separately. Caffeine increased the expression of UV-enhanced reactivation, while causing a small decrease in the `induction¿of enhanced reactivation.

Category: Journal Article
PubMed ID: #6264513 DOI: 10.1111/j.1751-1097.1981.tb04309.x
Includes FDA Authors from Scientific Area(s): Medical Devices
Entry Created: 2012-12-08