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U.S. Department of Health and Human Services

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Pharmacogenomics 2013 Jun;14(8):969-80

Pharmacogenomic biomarkers for personalized medicine.

Chen JJ, Lin WJ, Chen HC


Pharmacogenomics examines how the benefits and adverse effects of a drug vary among patients in a target population by analyzing genomic profiles of individual patients. Personalized medicine prescribes specific therapeutics that best suit an individual patient. Much current research focuses on developing genomic biomarkers to identify patients, to identify which patients would benefit from a treatment, have an adverse response, or no response at all, prior to treatment according to relevant differences in risk factors, disease types and/or responses to therapy. This review describes the use of the two personalized medicine biomarkers, prognostic and predictive, to classify patients into subgroups for treatment recommendation.

Category: Journal Article, Review
PubMed ID: #23746190 DOI: 10.2217/pgs.13.75
Includes FDA Authors from Scientific Area(s): Toxicological Research
Entry Created: 2013-06-12 Entry Last Modified: 2013-08-11