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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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Clin Vaccine Immunol 2014 Mar;21(3):453-5

Time to detection of Mycobacterium tuberculosis using the MGIT 360 system correlates with colony counting in the pre-clinical testing of new vaccines.

Kolibab K, Yang A, Parra M, Derrick SC, Morris SL


Clinical studies have suggested that the enumeration of mycobacteria by automated liquid systems is a faster and simpler alternative to quantitative cultures. Here we show that the Time to Detection of M. tuberculosis growth as measured by the MGIT 360 liquid culture system inversely correlates with CFU culture on solid media and that mycobacterial quantification using the MGIT system is faster and easier to perform than CFU plating.

Category: Journal Article
PubMed ID: #24371256 DOI: 10.1128/CVI.00742-13
PubMed Central ID: #PMC3957671
Includes FDA Authors from Scientific Area(s): Biologics Drugs
Entry Created: 2013-10-31 Entry Last Modified: 2014-10-16