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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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J Infect Dis 2015 May 1;211(9):1447-50

Intradermal inactivated poliovirus vaccine: a preclinical dose-finding study.

Kouiavskaia D, Mirochnitchenko O, Dragunsky E, Kochba E, Levin Y, Troy S, Chumakov K


Intradermal delivery of vaccines has been shown to result in dose sparing. We tested the ability of fractional doses of inactivated poliovirus vaccine (IPV) delivered intradermally to induce levels of serum poliovirus-neutralizing antibodies similar to immunization through intramuscular route. Immunogenicity of fractional doses of IPV was studied by comparing intramuscular and intradermal immunization of Wistar rats using NanoPass MicronJet600® microneedles. Intradermal delivery of partial vaccine doses induced antibodies at titers comparable to those after immunization with full human dose delivered intramuscularly. The results suggest that intradermal delivery of IPV may lead to dose-sparing effect and reduction of the vaccination cost.

Category: Journal Article
PubMed ID: #25391313 DOI: 10.1093/infdis/jiu624
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2014-06-04 Entry Last Modified: 2016-03-17