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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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Compr Rev Food Sci Food Saf 2014 Jul;13(4):705-29

Methods to Evaluate Uptake of Engineered Nanomaterials by the Alimentary Tract

Alger H, Momcilovic D, Carlander D, Duncan TV


This article is one of a series of 4 that report on a task of the NanoRelease Food Additive project of the International Life Science Institute Center for Risk Science Innovation and Application to identify, evaluate, and develop methods that are needed to confidently detect, characterize, and quantify intentionally produced engineered nanomaterials (ENMs) released from food along the alimentary tract. This particular article focuses on the problem of detecting and characterizing ENMs in the various compartments of the alimentary tract after they have been ingested from dietary sources. An in depth analysis of the literature related to oral toxicity of ENMs is presented, paying particular attention to analytical methodology and sample preparation. The review includes a discussion of model systems that can be used to study oral uptake of ENMs in the absence of human toxicological data or other live-animal studies. The strengths and weaknesses of various analytical and sample preparation techniques are discussed. The article concludes with a summary of findings and a discussion of potential knowledge gaps and targets for method development in this area.

Category: Journal Article, Review
DOI: 10.1111/1541-4337.12077
Includes FDA Authors from Scientific Area(s): Food Animal and Veterinary
Entry Created: 2014-07-28