Scientific Publications by FDA Staff

Clin Vaccine Immunol 2017 Jan 5;24(1):e00509-16

Trained immunity and susceptibility to HIV.

Derrick SC

In this issue of Clinical and Vaccine Immunology, Jensen et al. describe a dual purpose SIV/Mycobacterium tuberculosis vaccine (AMTB-SIV). Interestingly, immunized infant macaques required fewer oral exposures with SIV to become infected relative to non-immunized animals. The authors hypothesized that augmented susceptibility to SIV was due to activation of CD4+ T cells through trained immunity. This commentary explores the possible relationship between trained immunity, enhanced CD4 T cell responses and increased susceptibility to HIV.