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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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Clin Vaccine Immunol 2017 Jan 5;24(1):e00509-16

Trained immunity and susceptibility to HIV.

Derrick SC


In this issue of Clinical and Vaccine Immunology, Jensen et al. describe a dual purpose SIV/Mycobacterium tuberculosis vaccine (AMTB-SIV). Interestingly, immunized infant macaques required fewer oral exposures with SIV to become infected relative to non-immunized animals. The authors hypothesized that augmented susceptibility to SIV was due to activation of CD4+ T cells through trained immunity. This commentary explores the possible relationship between trained immunity, enhanced CD4 T cell responses and increased susceptibility to HIV.

Category: Journal Article, Editorial
PubMed ID: #27847369 DOI: 10.1128/CVI.00509-16
PubMed Central ID: #PMC5216436
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2017-03-21 Entry Last Modified: 2017-04-03