Scientific Publications by FDA Staff

J Biopharm Stat 2017;27(1):175-85

Multiple contrast type tests for the evaluation of animal carcinogenicity studies.

Rahman M, Tiwari R

The Cochran-Armitage (CA) test is frequently used for testing the dose-response relationship in tumor incidence. This test is based on a weighted linear regression of proportions. It is well known that the CA test lacks power for nonlinear tumor outcomes. For general shape of outcomes, Hothorn and Bretz (2000) proposed a multiple contrast (MC) test. This test suggests the use of the maximum over several single contrasts, where each of them is chosen appropriately to cover a specific dose-response shape. In this work, two new test procedures are proposed and they are compared to the CA and MC tests using power.