Scientific Publications by FDA Staff

J Appl Physiol 2017 Jul 1;123(1):172-81

Progression and variability of physiologic deterioration in an ovine model of lung infection sepsis.

Yaghouby F, Daluwatte C, Fukuda S, Nelson C, Salsbury J, Kinsky MP, Kramer GC, Strauss DG, Enkhbaatar P, Scully CG

In this study, a lung infection model of pneumonia in sheep (N=12) that included smoke inhalation injury followed by Methicillin-resistant Staphylococcus aureus (MRSA) placement into the lungs was used to investigate hemodynamic and pulmonary dysfunctions during the course of sepsis progression. To assess the variability in disease progression, animals were retrospectively divided into survivor (N=6) and non-survivor (N=6) groups and a range of physiological indices reflecting hemodynamic and pulmonary function were estimated and compared to evaluate variability in dynamics underlying sepsis development. Blood pressure and heart rate variability analyses were performed to assess whether they discriminated between the survivor and non-survivor groups early-on and after intervention. Results showed hemodynamic deterioration in both survivor and non-survivor animals during sepsis along with a severe oxygenation disruption (decreased SpO2) in non-survivors separating them from survivor animals of this model. Variability analysis of beat-to-beat heart rate and blood pressure reflected physiologic deterioration during infection for all animals, but these analyses did not discriminate the non-survivor animals from survivor animals.