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Cell Stem Cell 2017 Jul 6;21(1):14-7

The evolving roles of human iPSC-derived cardiomyocytes in drug safety and discovery.

Gintant G, Fermini B, Stockbridge N, Strauss D

Abstract

Nonclinical studies of drug effects with human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide new possibilities for evaluating drug safety and efficacy. The Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm provides lessons from the cardiac field that also apply to drug studies with other stem cell-based assays.

Category: Journal Article
PubMed ID: #28686863 DOI: 10.1016/j.stem.2017.06.005
Includes FDA Authors from Scientific Area(s): Drugs
Entry Created: 2017-07-09 Entry Last Modified: 2017-07-25
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