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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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Pathog Dis 2018 Mar 1;76(2):fty010

Transcriptomic profiling of Clostridium difficile grown under microaerophillic conditions.

Giordano N, Hastie JL, Carlson PE Jr


Clostridium difficile (Cd) is an anaerobic, spore-forming bacterium capable of colonizing the gastrointestinal tract of humans. Colonization usually occurs following antibiotic induced disruption of the host microbiota, which also leads to an increase in oxygen within the gastrointestinal tract. We sought to understand how Cd responds to this microaerophilic condition that is likely experienced within the host. Transcriptome profiling showed differential regulation of genes involved in sugar metabolism, pyruvate metabolism, and stress responses. These data provide insight into potential mechanisms of Cd adaptation to the host environment and should lead to the elucidation unknown mechanisms of Cd oxygen resistance and pathogenesis.

Category: Journal Article
PubMed ID: #29390060 DOI: 10.1093/femspd/fty010
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2018-01-21 Entry Last Modified: 2018-08-12