Scientific Publications by FDA Staff

Int J Infect Dis 2020 Aug 3 [Epub ahead of print]

Marburg virus disease: a summary for clinicians.

Kortepeter MG, Dierberg K, Shenoy ES, Cieslak TJ, Bhadelia N, Cieslak TJ, Davey RT, Dierberg K, Evans JD, Frank MG, Grein J, Kortepeter MG, Kraft CS, Kratochvil CJ, Martins K, McLellan S, Measer G, Mehta AK, Raabe V, Risi G, Sauer L, Shenoy ES, Uyeki T, Medical Countermeasures Working Group of the National Ebola Training and Education Center’s (NETEC’s) Special Pathogens Research Network (SPRN)

OBJECTIVES: This article is a summary of countermeasures for Marburg virus disease focusing on pathogenesis, clinical features, and diagnostics, with an emphasis on therapies and vaccines that have demonstrated potential for use in an emergency situation, through their evaluation in nonhuman primates (NHPs) and/or in humans. METHODS: A standardized literature review was conducted on vaccines and treatments for each pathogen, with a focus on human and nonhuman primate data published in the last five years. More detail on the methods used are summarized in a companion methods paper. RESULTS: We identified six treatments and four vaccine platforms that have demonstrated potential benefit for treating or preventing infection in humans, through their efficacy in NHPs. CONCLUSION: We provide succinct summaries of Marburg countermeasures to give the busy clinician a head start in reviewing the literature if faced with a patient with Marburg virus disease. We also provide links to other authoritative sources of information.