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J Clin Microbiol 2004 Apr;42(4):1739-1741

DNA Polymorphism Assay Distinguishes Isolates of Leishmania donovani That Cause Kala-Azar from Those That Cause Post-Kala-Azar Dermal Leishmaniasis in Humans.

Sreenivas G, Subba Raju BV, Singh R, Selvapandiyan A, Duncan R, Sarkar D, Nakhasi HL, Salotra P

Salotra P, ICMR, Inst Pathol, Safdarjung Hosp Campus, New Delhi 110029, India ICMR, Inst Pathol, New Delhi 110029, India Indian Inst Chem Biol, Kolkata, India US FDA, Ctr Biol Evaluat & Res, Div Emerging & Transfus Transmitted Dis, Off Blood Res & Review, Rockville, MD 20892 USA


Leishmania donovani in India causes visceral infection (kala-azar) and dermal infection (post-kala-azar dermal leishmaniasis). We report here the identification of polymorphism in a well-defined genetic locus among the Leishmania parasites causing the visceral and dermal manifestations, in a comparison of 15 post-kala-azar dermal leishmaniasis and 12 kala-azar patient isolates.

Category: Journal Article, Peer
PubMed ID: #15071036
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2011-10-04 Entry Last Modified: 2013-06-23