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Welcome to OTC Monographs@FDA
Your comprehensive resource for over-the-counter monograph drug information, administrative orders, and regulatory guidance.
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Latest News

07/28/2026 FDA posts Data Request: Use of pH Cycling Test Model as a Testing Procedure for Fluoride Dentifrice Drug Products in Over-the-Counter (OTC) Monograph M021: Anticaries Drug Products for Over-the-Counter Human Use.

About OTC Monographs@FDA

OTC Monographs@FDA provides a comprehensive resource for the public to view Administrative Orders (Proposed, Final, and Interim Final Orders) for OTC Monograph Drugs and view OTC Monographs. This platform also facilitates the ability for the public to submit, search, and view comments and data for Proposed and Interim Final Administrative Orders.

Some features incorporated by reference herein are available for inspection at FDA. For further information about requesting incorporation material, contact druginfo@fda.hhs.gov.

To learn more about OTC monographs and find answers to common questions, visit the frequently asked questions.

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OTC Monographs

Search OTC Monographs and Non-Monograph Guidelines.

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Administrative Orders

Search proposed, interim final, or final administrative orders including supporting documents and public comments.

SEARCH ORDERS
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Comment on Proposed or Interim Final Orders

Comment on administrative orders with open comment periods.

COMMENT ON ORDERS
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