Case reference number (b)(4) is a spontaneous report sent on 26-mar-2020 by a physician which refers to a male patient aged (b)(6) years.No information about medical history, concomitant medication, history of allergies or previous treatment had been reported.On an unknown date in (b)(6) 2019, the patient received treatment with durolane in his left knee (unknown amount, lot number, injection technique and needle type).On (b)(6) 2019, the patient experienced massive knee effusion(injection site joint effusion) within 48 to 72 hours following the procedure.He required weekly knee aspirations (about 5 sessions).In (b)(6) 2019, the patient experienced burning sensation(injection site pain) and itching(injection site pruritus) all over the body about 2 weeks following the procedure.He consulted dermatologists who had concurred that it was due to the allergic reaction(hypersensitivity) to injection sodium hyluronate.The knee effusion subsided following repeated treatment with injection depomedrol.The burning and itching have subsided with low dose oral steroids (tab deflazocort 6mg).Additional clarification was received that confirmed the patient was admitted for 7 days post durolane injection and received low dose steroid at the hospital.Treatment for the adverse event included tablet deflazocort [glucocorticoids] and injection depomedrol [methylprednisolone].Outcome at the time of the report: massive knee effusion was recovered/resolved.Allergic reaction was recovered/resolved.Burning sensation was recovered/resolved.Itching was recovered/resolved.
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