It is reported in the literature titled ¿comparison between endoscopic submucosal dissection and surgery in patients with early gastric cancer,¿ patients experienced adverse events during/after endoscopic submucosal dissection procedures.Summary: conventional gastrectomy combined with regional lymph node dissection has been the standard treatment for early gastric cancer (egc).This retrospective case¿control study aimed to compare the clinical outcomes of endoscopic submucosal dissection (esd) and surgical resection for egc in china.After propensity score-matching, there were no significant differences between the two groups for overall survival (os), recurrence free survival (rfs), and disease specific survival (dss).Additionally, with similar r0 resection and recurrence rates, the esd group showed less blood loss, fewer adverse events, lower hospital cost, and a shorter operative time and hospital duration than the surgery group.Therefore, esd can be a first-line treatment of egc in addition to surgery.Endoscopic submucosal dissection (esd) has become a preferred treatment option for early gastric cancer (egc).This study aimed to compare the clinical outcomes of esd and surgical resection for egc.Methods: this was a retrospective case¿control study.Patients with a diagnosis of egc who underwent esd or surgery in our hospital from 2011 to 2020 were enrolled.We compared the clinical characteristics and treatment outcomes of these two groups according to propensity score-matching.The primary outcome comparison was overall survival (os).Secondary outcomes were disease-specific survival (dss), recurrence-free survival (rfs), and treatment-related events.Results: in the matched cohort, the esd group showed comparable os, rfs, and dss with the surgery group.Statistical differences were shown in blood loss and adverse events.Furthermore, the esd group showed lower hospital cost, as well as a shorter operative time and hospital duration than the surgery group.The r0 resection and recurrence rates were similar between the two groups.In cox regression analysis, age, tumor size, poor differentiation, and lymphovascular invasion were regarded as independent factors of os.Conclusions: with sufficient safety and advantages, esd can be a first-line treatment of egc.Preoperative evaluation is vital to the appropriate treatment and prognosis.The clinical outcomes are summarized.Patients in the esd group had less blood loss, a shorter operative time and hospital duration, and a lower hospital cost (all p < 0.001).There was no statistically significant difference in the r0 resection rate and the recurrence rate.Additionally, the esd group had significantly fewer adverse events compared with the surgery group (p < 0.001).In the matched population, these variables (including estimated blood loss, operative time, hospital duration, hospital cost, and adverse events) still showed statistically significant differences between the esd and surgery groups (p < 0.001).There is no report of olympus device malfunction reported in any procedure described in this literature.Case with patient identifier (b)(6) reports patient one of seven.Case with patient identifier (b)(6) reports patient two of seven.Case with patient identifier (b)(6) reports patient three of seven.Case with patient identifier (b)(6) reports patient four of seven.Case with patient identifier (b)(6) reports patient five of seven.Case with patient identifier (b)(6) reports patient six of seven.Case with patient identifier (b)(6) reports patient seven of seven.
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