It was reported by gupta et al in an article entitled ¿can low dose rhbmp-2 replace iliac crest bone graft in achieving successful fusion in adults with a long fusion to the sacrum?¿ (spine journal, suppl.1 14.11 (nov 1, 2014): s158) that a retrospective review of patients with minimum 5-level fusions treated with ldbmp or icbg was studied from two centers.One center used ldbmp and the other icbg.Radiographic analysis and chart review was performed.Minimum follow-up was 2 years.46 ldbmp and 43 icbg patients had adequate radiographic and clinical follow-up.The mean age was 63 years for both groups.The average follow-up was 25 months for ldbmp and 26 months for icbg.The total amount of rh-bmp-2 used in each patient was 1-3 large kits (12mg/kit).The average amount of rh-bmp-2 used was 18.52 mg (avg 1.78 mg/ level).There were 3 nonunions with icbg and 0 nonunions with ldbmp.The overall complication rate with ldbmp was 33% including 23% junctional breakdown, 6.52% cardiac, 0% neurologic, 6.52% respiratory, 4.34% gastrointestinal, 2.17% urological, with a total revision rate of 15.2 % percent.The efficacy of fusion, complication rate and reoperation rates were similar between the two groups.One patient in the bmp cohort developed urological complications post-op.
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Literature citation: gupta et al.Can low dose rhbmp-2 replace iliac crest bone graft in achieving successful fusion in adults with a long fusion to the sacrum? spine journal, suppl.1 14.11 (nov 1, 2014): s158.(b)(4).Neither the device nor films of applicable imaging studies were returned to the manufacturer for evaluation.Therefore, we are unable to determine the definitive cause of the reported event.
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