Patient with newly diagnosed glioblastoma began optune therapy on (b)(6) 2015.On (b)(6) 2015, patient presented to an outside area hospital with shortness of breath.Chest x-ray showed right lobe infiltrate concerning for pneumonia.Patient was admitted for the treatment of community acquired pneumonia with ceftriaxone and levofloxacin.Oxygenation continued to worsen and chest ct revealed new onset saddle pulmonary embolus (pe).Patient was treated with heparin infusion and transferred to the intensive care unit at prescribing site for further care.Upon presentation, patient was experiencing shortness of breath due to hypoxemic respiratory failure secondary to pe and pneumonia.Patient was started on ceftriaxone and azithromycin for treatment of pneumonia and continued on heparin drip for anticoagulation.Doppler ultrasound showed deep vein thrombosis (dvt) in right lower extremity.Echocardiogram showed ejection fraction (ef) 60-65% with mild dilation of right ventricle.Patient was thrombocytopenic throughout course.Patient transitioned to enoxaparin and platelet level increased.On (b)(6) 2015, patient deemed medically stable and was transferred from the icu to hematology/oncology.Patient continued to show improvement and was discharged to rehabilitation on (b)(6) 2015.Patient did not have a history of pe/dvt and was not on anti-coagulation therapy at the time of the event.Per prescribing physician, the cause of the pe/dvt was patient's hypercoagulable state secondary to glioblastoma and decreased mobility.The event was not related to optune therapy.Patient continues with optune therapy.
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