Autonotification received from (b)(6) 26-may-2020 as follows: site number : (b)(6), unique patient id : (b)(6), diagnostic term to describe primary sae: ascitis, seriousness criteria (saecrit): led to a serious deterioration in health, start date: (b)(6) 2020, severity (ctcae v5.0 grade): grade 2, causality related to administration procedure: not related, causality related to therasphere device: definitely.(b)(6) male patient.Obese patient with a bmi of 35.4, (b)(6) kg.Diagnoses with hcc (b)(6) 2020, etiology of underlying liver disease: alcohol, dysmetabolic.Tumour characteristics: multifocal, 2-4 lesions 4 mm diameter index lesion in, right liver segment viii, presence of pvt (tumoural), tumor burden 10%, no ehd.No prior anti-cancer treatments received.Main comorbidities: hyperglycemia, diabetes, coronary arterial disease, alcohol intake history, tobacco intake history, renal disease.Therasphere treatment - (b)(6) 2020 3.78 gbq administered to right liver via femoral artery.It was noted: significantly higher overall perfusion in tumour versus normal liver.Complete distribution (y90 distribution in 99-100% the all/near all the tumour volume).Event: on the (b)(6) 2020 the patient was admitted to the hospital for the occurrence of ascites, oedema, worsening of renal function, and hypoxemia, child b9.Action taken: concomitant medication.Oxygen, ascites removal.Discharged: (b)(6) 2020.Intervention: evacuation of the peritoneal fluid.
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