Case description: this serious spontaneous device report was received from a physician in the united states.A pt, a (b)(6) female experienced anaphylactic reaction, chest pain, trouble breathing, tongue swelling, lips swelling, rash, and skin tingling sensation after receiving the euflexxa injection (1% sodium hyaluronate) to the left knee for osteoarthritis.Lot number: unspecified expiration date: unspecified.On (b)(6) 2015, the female pt initiated euflexxa therapy and received her first injection.The pt reported that she took celebrex (celecoxib) after her injection on (b)(6) 2015 and within an hour after the euflexxa injection, the pt experienced chest pain, trouble breathing, tongue swelling, lips swelling, rash, and skin tingling sensation.The pt took two benadryl (diphenhydramine hci) without relief.The pt then went to the emergency room and she was given iv epinephrine, ib solumedrol, and pepcid (famotidine) and the pt's symptoms resolved.As per reporting physician, the pt was not admitted to the hospital and that this is the first anaphylactic reaction that he had seen with euflexxa.The physician did not think that the pt's events were related to euflexxa as there were different factors that could have caused the pt's reaction like the sanitation wipes that the physician's office used for their probes that may contain certain ingredients, pt's allergic history to (b)(6), and concomitant medication celebrex that contains sulfur.Medical history was provided and included past experience of similar symptoms as reported with (b)(6).Concomitant medication was provided.Sender comment: reporter causality: not related.
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