Citation: jia-sheng pei, peng-fan yang, qiao lin, yan-zeng jia, hui-jian zhang, ming-chao shang, zhong-hui zhong, shou-sen wang, neuronavigati on-assisted surgical treatments for medically refractory epilepsy: single-hospital experience with 4 surgical approaches, clinical neurology and neurosurgery, volume 182, 2019, pages 148-151, issn 0303-8467, https://doi.Org/10.1016/j.Clineuro.2019.01.010.Summary: objective: surgical treatment should be considered for patients with medically refractory epilepsy, and neuronavigation may benefit and reduce the technical difficulties during surgery.In this study, we aimed to report our single-hospital experience of incorporating neuronavigation for treating patients with medically refractory epilepsy using 4 types of surgery.Patients and methods: patients who were diagnosed as medically refractory epilepsy and received neuronavigation- assisted surgery were included in this retrospective analysis.The type of surgery was decided by the surgery committee after careful evaluation and discussion, including temporo-parietal-occipital (tpo) disconnection, anterior subtotal callosal section, functional hemispherectomy and resection of the epileptogenic zone(s).Postoperative seizure outcome at the last visit was evaluated using engel classification.Results: a total of 173 patients with medically refractory epilepsy who were treated surgically under the assistance of neuronavigation were included.The majority type of surgery was resection of epileptic zone, n=104 (60.12%).An excellent seizure outcome, engel class i was found in 50.86% of the patients, followed by 23.12% patients with a good outcome of engel class ii.Conclusion: overall more than half of the patients could have excellent seizure outcome of engel class i, the postoperative complications were manageable.These results indicated that the applicability of neuronavigation, and the use of neuronavigation provides good efficacy and safety for all kinds of surgical procedures for patients with medically refractory epilepsy.The navigation system was used for preoperative planning and intraoperative guidance.Anatomical marker points (e.G.Nasal, orbital and auricular points) or if not available i.E.Prone position, 5¿7 external fiducial markers were applied to the scalp for registration.Acquired images were transferred onto the workstation and a 3d model of the patient was reconstructed.After general anesthesia, the patient¿s head was placed in a non-medtronic three-point head fixation system, the dynamic reference frame was attached to the clamp, the anatomic or scalp fiducials were used for registration.The navigation system then estimated the accuracy of the mathematical match between the scan and physical space.If the error was larger than 2 millimeters, registration and calibration should be carried out again.Reported events: twenty-three patients who underwent tempro-parietal-occipital disconnection had contralateral visual field defect.Two patients who underwent tempro-parietal-occipital disconnection had cerebral edema and one needed craniotomy to remove the swelling tissue.One patient who underwent tempro-parietal-occipital disconnection had incision infection and surgical debridement was required.Eighteen patients who underwent anterior subtotal callosal section had disconnection syndromes.All were resolved within three weeks.Seven patients who underwent functional hemispherectomy had decreased muscle strength in contralateral extremities.Five patients recovered to preoperative levels within six months.Two patients still had decreased muscle strength in the left extremities.One patient who underwent resection of epileptic zone had decreased muscle strength in the left upper extremities.One patient with cerebral cavernous malformations had incision infection and recovered after oral administration of antibiotics.
|