Citation: bassaganyas-vancells, et al.¿combined use of 5-aminolevulinic acid and intraoperative low-field magnetic resonance imaging in high-grade glioma surgery.¿ world neurosurgery.Oct.2019;130:e206-e212.Https://doi.Org/10.1016/j.Wneu.2019.06.029 abstract: objective: we sought to assess the impact of 5-aminolevulinic acid (5-ala) a.Nd low-field intraoperative magnetic resonance imaging (imri) on the extent of resection of high-grade gliomas (hggs).Results are compared with those obtained when using 5-ala and imri separately.Methods: we retrospectively included patients with an hgg eligible for gross total resection (gtr) from january 2013 to january 2018.Patients were included according to 5-ala surgical guidance (5a-group), imri (imri-group), or both (5a-imri-group).Surgical variables were registered, and presurgical and postsurgical radiologic and clinical variables were analyzed.Extent of resection greater or equal to 90%, complications, and new permanent neurologic deficit were compared using the chi-squared and analysis of variance tests.Other variables studied were mortality, average hospital stay, surgical time, and karnofsky performance scale status before and after surgery.Results: most of the 118 procedures carried out were in men (59.2%).The mean age was 58 years.Sixty patients (50.8%) were operated on using exclusively 5-ala assistance (5a-group), 19 (16.1%) using imri (imri-group), and 39 (33%) combining both techniques (5a-imri-group).There were no statistically significant differences among 3 groups regarding extent of resection greater or equal to 90% (73% 5a, 73.7% imri, 71.8% 5a-imri, p = 0.94); complication rates (18.3% 5a, 5.3% imri, 7.7% 5a-imri, p = 0.17); new or worsening of preexisting neurologic deficit at 1-month follow-up (13.3% 5a, 10.5% imri, 15.4% 5a-imri, p = 0.26); average hospital stay in days (9.5 5a, 6.4 imri, 7.6 5a-imri, p = 0.18); karnofsky performance scale; nor surgical time in minutes (212.4 5a, 187.9 imri, 201.4 5a-imri, p = 0.13).Conclusions: in our experience, combined use of imri and 5-ala does not improve the studied variables when compared with those technologies when used separately, even though a slight tendency of a superior effectiveness is observed when using imri individually.Reported events: 1.4 patients in the 5a group had re-operations.2a.13 patients in the 5a group had an occurrence of a new neurologic deficit or worsening of preexisting deficit in the immediate p ostoperative period.2b.8 of these patients had these deficits remaining one month post-operatively.3.3 patients in the 5a group had superficial infections of the surgical wound (s.Aureus).4.1 patient in the 5a group had encephalitis (escherichia coli).5.2 patients in the 5a group had post-operative seizures.6.1 patient in the 5a group had an infarction of right anterior choroidal artery.7.1 patient in the 5a group had an epidural hematoma.8.3 patients in the 5a group had surgical bed hematomas.
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