FDA Drug Shortages

Current and Resolved Drug Shortages and Discontinuations Reported to FDA

A drug receives Resolved status when the Drug Shortages Staff (DSS) determines that the market is covered, based on information from all manufacturers. The market is considered covered when supply is available from at least one manufacturer to cover total market demand. However, some manufacturers may not have all presentations available. DSS monitors the supply of products with Resolved status. For the most current supply information, contact the manufacturers.

Generic Name or Active Ingredient Status
Acetazolamide Injection Currently in Shortage
Amifostine Injection Currently in Shortage
Amino Acids Currently in Shortage
Aminophylline Injection, USP Resolved
Amoxapine Tablets Currently in Shortage
Amphetamine Aspartate; Amphetamine Sulfate; Dextroamphetamine Saccharate; Dextroamphetamine Sulfate Tablets Currently in Shortage
Anagrelide Hydrochloride Capsules Currently in Shortage
Asparaginase Erwinia Chrysanthemi (Erwinaze) Currently in Shortage
Atropine Sulfate Injection Currently in Shortage
Atropine Sulfate Ophthalmic Ointment Currently in Shortage
Azacitidine for Injection Currently in Shortage
Azithromycin (Azasite) Ophthalmic Solution 1% Resolved
Azithromycin Tablets Resolved
Belatacept (Nulojix) Lyophilized Powder for Injection Currently in Shortage
Bumetanide Injection, USP Currently in Shortage
Bupivacaine Hydrochloride and Epinephrine Injection, USP Currently in Shortage
Bupivacaine Hydrochloride Injection, USP Currently in Shortage
Calcitriol Injection USP 1MCG /ML Currently in Shortage
Calcium Chloride Injection, USP Resolved
Calcium Disodium Versenate Injection Currently in Shortage
Calcium Gluconate Injection Currently in Shortage
Capreomycin Injection, USP Currently in Shortage
Cefazolin Injection Currently in Shortage
Cefepime Injection Resolved
Cefotaxime Sodium Injection Currently in Shortage
Cefotetan Disodium Injection Currently in Shortage
Cefoxitin for Injection, USP Currently in Shortage
Ceftazidime and Avibactam (AVYCAZ®) for Injection, 2 grams/0.5 grams Currently in Shortage
Ceftolozane and Tazobactam (Zerbaxa) Injection Currently in Shortage
Chlordiazepoxide Hydrochloride USP, Capsules Currently in Shortage
Chlorothiazide (Diuril) Oral Suspension Resolved
Cisatracurium Besylate Injection Currently in Shortage
Continuous Renal Replacement Therapy (CRRT) Solutions Currently in Shortage
Cortisone Acetate Tablets Currently in Shortage
Cyclopentolate Ophthalmic Solution Currently in Shortage
Cysteamine Hydrochloride Ophthalmic Solution Currently in Shortage
Cysteine Hydrochloride Injection Resolved
Deferoxamine Mesylate for Injection, USP Resolved
Desmopressin Acetate (Stimate) Nasal Spray Currently in Shortage
Dexamethasone Sodium Phosphate Injection Currently in Shortage
Dexmedetomidine Injection Currently in Shortage
Dextrose 25% Injection Resolved
Dextrose 5% Injection Bags Resolved
Dextrose 50% Injection Resolved
Dicyclomine Oral Tablets/Capsules Resolved
Difluprednate (Durezol) Ophthalmic Emulsion Resolved
Diltiazem Hydrochloride Injection Currently in Shortage
Dimercaprol (Bal in Oil) Injection USP Currently in Shortage
Diphenhydramine Injection Resolved
Disopyramide Phosphate (Norpace) Capsules Currently in Shortage
Dobutamine Hydrochloride Injection Currently in Shortage
Dopamine Hydrochloride Injection Currently in Shortage
Dorzolamide Hydrochloride and Timolol Maleate (Cosopt) Ophthalmic Solution Currently in Shortage
Dorzolamide Hydrochloride Ophthalmic Solution Currently in Shortage
Doxycycline Hyclate Injection Resolved
Echothiophate Iodide (Phospholine Iodide) Ophthalmic Solution Currently in Shortage
Enalaprilat Injection, USP Currently in Shortage
Epinephrine Injection, 0.1 mg/mL Currently in Shortage
Epinephrine Injection, Auto-Injector Currently in Shortage
Erythromycin Lactobionate for Injection, USP Resolved
Erythromycin Ophthalmic Ointment Currently in Shortage
Etomidate Injection Currently in Shortage
Famotidine Injection Currently in Shortage
Famotidine Tablets Currently in Shortage
Fentanyl Citrate (Sublimaze) Injection Currently in Shortage
Floxuridine for Injection, USP Currently in Shortage
Fludrocortisone Acetate Tablets Resolved
Fluorescein Injection Resolved
Fluorescein Strips Currently in Shortage
Flurazepam Hydrochloride Capsules Resolved
Fluvoxamine ER Capsules Currently in Shortage
Furosemide Injection, USP Currently in Shortage
Gemifloxacin Mesylate (Factive) Tablets Currently in Shortage
Guanfacine Hydrochloride Tablets Currently in Shortage
Haloperidol Tablets Resolved
Heparin Sodium and Sodium Chloride 0.9% Injection Currently in Shortage
Histreline Acetate Implant Currently in Shortage
Hydralazine Hydrochloride Injection, USP Currently in Shortage
Hydrocortisone Tablets, USP Currently in Shortage
Hydromorphone Hydrochloride Injection, USP Currently in Shortage
Hydroxyprogesterone Caproate Injection Resolved
Hydroxypropyl (Lacrisert) Cellulose Ophthalmic Insert Currently in Shortage
Hydroxyzine Pamoate Oral Capsules Resolved
Imipenem and Cilastatin for Injection, USP Currently in Shortage
Isoniazid Injection USP Currently in Shortage
Ketamine Injection Currently in Shortage
Ketoprofen Capsules Currently in Shortage
Ketorolac Tromethamine Injection Currently in Shortage
Labetalol Hydrochloride Injection Resolved
Letermovir (Prevymis) Injection Currently in Shortage
Leucovorin Calcium Lyophilized Powder for Injection Currently in Shortage
Leuprolide Acetate Injection Currently in Shortage
Levetiracetam Extended-Release Oral Tablets, USP Resolved
Levetiracetam Immediate-Release Oral Tablets, USP Resolved
Lidocaine Hydrochloride (Xylocaine) and Dextrose Injection Solution-Premix Bags Currently in Shortage
Lidocaine Hydrochloride (Xylocaine) Injection Currently in Shortage
Lidocaine Hydrochloride (Xylocaine) Injection with Epinephrine Currently in Shortage
Lithium Oral Solution Currently in Shortage
Lorazepam Injection, USP Currently in Shortage
Loxapine Capsules Currently in Shortage
Methadone Hydrochloride Injection Currently in Shortage
Methyldopa Tablets Currently in Shortage
Metoclopramide Injection, USP Resolved
Metoprolol Tartrate Injection, USP Resolved
Metronidazole Injection, USP Resolved
Midazolam Injection, USP Currently in Shortage
Misoprostol Tablets Currently in Shortage
Morphine Sulfate Injection Currently in Shortage
Multi-Vitamin Infusion (Adult and Pediatric) Currently in Shortage
Nalbuphine Hydrochloride Injection Currently in Shortage
Nefazodone Hydrochloride Tablets Currently in Shortage
Nizatidine Capsules Currently in Shortage
Ondansetron Hydrochloride Injection Currently in Shortage
Oxytocin Injection, USP Synthetic Currently in Shortage
Pantoprazole Sodium for Injection Currently in Shortage
Parathyroid Hormone (Natpara) Injection Currently in Shortage
Pentamidine Isethionate (Nebupent) For Inhalation Solution Resolved
Phenytoin Sodium Injection, USP Resolved
Physostigmine Salicylate Injection, USP Currently in Shortage
Pindolol Tablets Currently in Shortage
Potassium Acetate Injection, USP Currently in Shortage
Prednisolone Acetate 1% Ophthalmic Suspension Resolved
Procainamide Hydrochloride Injection, USP Resolved
Progesterone Injection, USP Resolved
Promethazine (Phenergan) Injection Currently in Shortage
Propofol Injectable Emulsion Currently in Shortage
Rifampin Injection Currently in Shortage
Rifapentine Tablets Currently in Shortage
Rocuronium Bromide Injection Resolved
Ropivacaine Hydrochloride Injection Currently in Shortage
Sclerosol Intrapleural Aerosol Currently in Shortage
Scopolamine Transdermal System Resolved
Sertraline Hydrochloride Oral Solution, USP Resolved
Sertraline Hydrochloride Tablets Resolved
Sildenafil Citrate (REVATIO) Resolved
Sincalide (Kinevac) Lyophilized Powder for Injection Currently in Shortage
Sodium Acetate Injection, USP Currently in Shortage
Sodium Bicarbonate Injection, USP Currently in Shortage
Sodium Chloride 0.9% Injection Bags Resolved
Sodium Chloride 23.4% Injection Currently in Shortage
Sodium Chloride Injection USP, 0.9% Vials and Syringes Currently in Shortage
Sterile Water Resolved
Succimer (Chemet) Capsules Currently in Shortage
Sulfasalazine Tablets Currently in Shortage
Tacrolimus Capsules Currently in Shortage
Technetium Tc99m Succimer Injection (DMSA) Currently in Shortage
Teprotumumab-trbw Currently in Shortage
Thiothixene Capsules Currently in Shortage
Timolol Maleate Ophthalmic Gel Forming Solution Currently in Shortage
Timolol Maleate Ophthalmic Solution Currently in Shortage
Timolol Maleate Tablets Resolved
Tobramycin Lyophilized Powder for Injection Resolved
Triamcinolone Acetonide (Triesence) Injection, Suspension Resolved
Trifluridine Ophthalmic Solution Resolved
Trimethobenzamide Hydrochloride Capsules Currently in Shortage
Valproate Sodium Injection, USP Currently in Shortage
Vecuronium Bromide for Injection Currently in Shortage
Zinc Acetate Capsules Currently in Shortage
Zolpidem Tartrate (Edluar) Sublingual Tablets Resolved

Discontinuations Listed by Generic Name or Active Ingredient

Companies are required under Section 506C of the Federal Food, Drug, and Cosmetic Act (FD&C Act) (as amended by the Food and Drug Administration Safety and Innovation Act) to notify FDA of a permanent discontinuance of certain drug products, six months in advance, or if that is not possible, as soon as practicable. These drugs include those that are life-supporting, life-sustaining or for use in the prevention or treatment of a debilitating disease or condition, including any such drug used in emergency medical care or during surgery. The discontinuations listed on the site reflect information received from manufacturers and are for informational purposes only.

Withdrawal notifications can be found here: https://www.federalregister.gov

Generic Name or Active Ingredient
Abacavir Sulfate and Lamivudine Tablets
Abiraterone Acetate Tablets
Acetaminophen/Tramadol Hydrochloride (Ultracet) Tablets
Acrivastine and Pseudoephedrine Hydrochloride Capsules
Acyclovir Ointment, USP 5%
Adalimumab (Humira) Pre-filled Syringe
Adapalene/Benzoyl Peroxide Topical Gel
Alfentanil Injection
Amantadine Hydrochloride Capsules
Amiodarone Tablets
Ampicillin for Injection, USP
Anastrozole Tablets
Argatroban Injection
Asenapine (Saphris®) Sublingual Tablets
Asenapine Maleate (Saphris®) Sublingual Tablets
Aspirin/Dipyridamole (Aggrenox) Extended Release Capsules
Bethanechol Chloride Tablets
Betrixaban (Bevyxxa) Capsules
Budesonide Capsules
Bumetanide Tablets
Busulfan Injection
Carbidopa, Levodopa and Entacapone, Tablets
Carboplatin Injection
Cardene IV (nicardipine hydrochloride) 0.2 mg/mL in 5% Dextrose
Carisoprodol, Aspirin, and Codeine Phosphate Tablets USP
Caspofungin Acetate Injection
Cefazolin Injection
Cefdinir Capsules
Cefepime Injection
Cefotetan Disodium Injection
Ceftazidime (Fortaz) Injection
Cefuroxime Sodium (Zinacef) Injection
Chlordiazepoxide Hydrochloride USP, Capsules
Chlorothiazide Injection
Cleocin-T 1%
Clindamycin Injection, USP
Clobetasol Propionate Topical Solution, USP 0.05%
Clonazepam Tablets
Clonidine Tablets
Clozapine (FazaClo® ) Orally Disintegrating Tablets
Coumadin Tablets
Dacarbazine for Injection, USP
Darifenacin Hydrobromide Tablets
Dasabuvir Sodium; Ombitasvir; Paritaprevir; Ritonavir (Viekira XR) Tablets
Deferasirox Tablets
Demeclocycline Hydrochloride Tablets, USP
Desogestrel and Ethinyl Estradiol Tablets (ORTHO-CEPT)
Dexmedetomidine Injection
Dexrazoxane Injection
Dextroamphetamine Sulfate Extended-Release Capsules
Diclofenac Sodium Extended Release Tablets
Diclofenac Sodium Topical Gel
Diclofenac Sodium Topical Solution
Didanosine Delayed-Release Capsules USP
Diltiazem Hydrochloride
Diltiazem Hydrochloride Injection
Diphenhydramine Hydrochloride Injection, USP
Disulfiram Tablets
Dobutamine Hydrochloride Injection
Docetaxel Injection
Donepezil Hydrochloride Tablets
Dorzolamide Hydrochloride and Timolol Maleate (Cosopt) Ophthalmic Solution
Dorzolamide Hydrochloride Ophthalmic Solution
Doxorubicin Hydrochloride Injection
Dutasteride Capsules
Echothiophate Iodide (Phospholine Iodide) Ophthalmic Solution
Efavirenz; Emtricitabine; Tenofovir Disoproxil Fumarate (Atripla) Tablets
Enalaprilat Injection, USP
Enoxaparin Sodium Injection
Entecavir Tablets
Eprosartan Mesylate Tablets
Eptifibatide (Integrilin) Injection
Ergotamine Tartrate and Caffeine (Cafergot) Tablets
Erlotinib Hydrochloride Tablets
Erythromycin Ethylsuccinate Powder for Suspension
Estradiol (Alora) Patch
Ethacrynic Acid Tablets
Ethambutol Hydrochloride Tablets
Ethinyl Estradiol; Norgestrel Tablets
Etomidate (Amidate) Injection
Etoposide Injection
Exenatide (BYDUREON) Extended Release for Injectable Suspension
Ezetimibe Tablets
Fenoldopam Mesylate (Corlopam) Injection, USP
Fentanyl (Duragesic 100, 12, 25, 37, 50, 75) Extended-Release Film
Finasteride Tablets
Floxuridine for Injection, USP
Fludarabine Phosphate for Injection, USP
Flumazenil Injection
Fluorouracil Injection
Fluoxetine Capsules
Fluoxetine Tablets
Furosemide Tablets
Gemcitabine Hydrochloride Injection
Glipizide Tablets
Glycopyrrolate (Seebri Neohaler) Inhalation Powder
Guanidine Hydrochloride Tablets
Haloperidol Lactate (Haldol) Injection
Haloperidol Lactate Injection
Hydrochlorothiazide and Lisinopril Tablets
Hydrocodone Bitartrate and Homatropine Methylbromide Oral Solution
Hydrocodone/Homatropine Tablets
Hydrocortisone Acetate Suppository
Hydroxychloroquine Sulfate Tablets
Indacterol Maleate (Arcapta Neohaler) Inhalation Powder
Indacterol Maleate and Glycopyrrolate (Utibron Neohaler) Inhalation Powder
Indinavir (CRIXIVAN) Capsules
Indomethacin Capsules
Ipratropium Bromide Inhalation Solution
Isoniazid Tablets
Ketoprofen Capsules
Lamivudine and Zidovudine Tablets
Lamivudine Tablets
Lanoxin (digoxin) Tablets
Levocetirizine Dihydrochloride Tablets
Levofloxacin Tablets
Levoleucovorin Calcium Injection
Lidocaine HCl Topical Jelly
Liothyronine Sodium Tablets
Lisinopril Tablets
Loxapine Capsules
Meclizine Hydrochloride Tablets
Medroxyprogesterone Acetate (Depo-Provera) Injection, Suspension
Medroxyprogesterone Acetate (Provera) Tablet
Mesalamine (CANASA®) Suppositories
Metformin Hydrochloride Extended Release Tablets
Metformin Hydrochloride Tablets
Methocarbamol Tablet, USP
Methotrexate Sodium Injection
Methoxsalen Capsules
Methscopolamine Bromide Tablets
Methylprednisolone Tablets
Metoprolol Tartrate Tablets
Metronidazole (Flagyl) Tablets
Miglitol Tablets
Minocycline Hydrochloride Extended-Release Tablets, USP
Mirtazapine Orally Disintegrating Tablets
Misoprostol Tablets
Montelukast Sodium Chewable Tablet
Montelukast Sodium Tablets
Morphine Sulfate Extended-Release Tablets
Morphine Sulfate Injection, USP
Mycophenolic Acid Delayed Release Tablets
Nadolol Tablets
Nafcillin Sodium Injection
Neomycin Sulfate, Polymyxin B Sulfate and Hydrocortisone Acetate Cream
Neomycin Sulfate, Polymyxin B Sulfate, Bacitracin Zinc and Hydrocortisone Ointment
Nesiritide Powder (NATRECOR) for Injection
Nevirapine (Viramune) Tablets
Nevirapine Extended Release Tablets
Nizatidine Capsules
Norethindrone (NOR QD) Tablets
Norethindrone Acetate/Ethinyl Estradiol (Femhrt) Tablets
Norethindrone Acetate/Ethinyl Estradiol/Ferrous Fumarate Kit
Norethindrone/Ethinyl Estradiol Kit
Ocriplasmin (Jetrea) Injection
Olanzapine and Fluoxetine (Symbyax) Capsules
Olopatadine Hydrochloride Ophthalmic Solution
Ombitasvir; Paritaprevir; Ritonavir (Technivie) Tablets
Oxalaplatin Injection
Paclitaxel Injection, USP
Paricalcitol Injection
Peginterferon alfa-2b (Sylatron)
Penicillin V Potassium Tablets
Pentoxifylline Extended-Release Tablets
Phenobarbital Oral Solution
Pioglitazone Hydrochloride and Metformin Hydrochloride Tablets
Pramipexole Dihydrochloride Extended Release Tablets
Pravastatin Sodium (Pravachol) Tablets
Prinivil Tablets
Promethazine Hydrochloride Injection, Solution
Promethazine Suppository
Pyrazinamide Tablets, USP
Rabeprazole Sodium Delayed Release Tablets
Ranitidine Injection, USP
Ranitidine Tablets/Capsules
Ranolazine Extended Release Tablets
Repaglinide Tablets
Rifampin (Rifadin) Capsules
Rifampin Capsules
Rifampin/Isoniazid (Rifamate) Capsules
Rifampin/Isoniazid/Pyrazinamide (Rifater) Tablets
Risedronate Tablets
Risperidone Tablets
Rivastigmine Tartrate Capsules
Saquinavir Mesylate (Invirase) 200mg Capsules
Simeprevir Capsules
Simvastatin (Zocor) Tablets
Sodium Lactate Injection, USP
Somatropin Recombinant (Humatrope) Injection
Spironolactone Tablets
Stavudine Capsules
Sumatriptan (Sumavel DosePro) Injection
Sumatriptan Succinate (Imitrex) Injection
Sumatriptan Succinate Injection
Talwin (Pentazocine Lactate Injection, USP, CIV)
Telmisartan and Amlodipine (Twynsta) Tablets
Temozolomide (TEMODAR) Capsules
Temozolomide Capsules
Testosterone Topical Gel
Theophylline Extended Release Tablets and Capsules
Tizanidine Hydrochloride Tablets
Tolcapone Tablets
Tositumomab and Iodine I 131 Tositumomab (Bexxar)
Tramadol Hydrochloride (Ultram) Tablets
Trandolapril Tablets
Tranexamic Acid Tablets
Trazodone Tablets
Triamcinolone Acetonide Cream
Triamterene and Hydrochlorothiazide (Dyazide) Capsules
Triamterene and Hydrochlorothiazide Tablets
Trimethobenzamide Hydrochloride Capsules
Ursodiol (Actigall) Capsules
Valsartan Tablets
Vardenafil Hydrochloride Tablets
Vinorelbine Tartrate Injection
Zoledronic Acid Injection
Zolpidem Tartrate Extended Release Tablets

Analgesia/Addiction

Anesthesia

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Cardiovascular

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    Endocrinology/Metabolism

    Gastroenterology

    Hematology

    Inborn Errors

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  • Medical Imaging

    Musculoskeletal

    Neurology

    Oncology

    Ophthalmology

    Other

    Pediatric

    Psychiatry

    Pulmonary/Allergy

    Renal

    Reproductive

    Rheumatology

    Total Parenteral Nutrition

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    Urology

    New

    April 14, 2021

    April 08, 2021

    April 07, 2021

    April 06, 2021

    March 31, 2021

    Updated

    April 13, 2021

    April 12, 2021

    April 08, 2021

    April 07, 2021

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